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    您當前的位置:首頁 > 技術文章 > ELISA試劑盒耳聾、常染色體隱性遺傳22抗體分析

    ELISA試劑盒耳聾、常染色體隱性遺傳22抗體分析

    發(fā)布時間: 2014-04-23  點擊次數(shù): 825次

    ELISA試劑盒耳聾、常染色體隱性遺傳22抗體英文名稱  Anti-OTOA/DFNB22 
    中文名稱  耳聾、常染色體隱性遺傳22抗體 
    別    名  Cancer/testis antigen 108; CT108; Deafness, autosomal recessive 22; DFNB22; OTOA; OTOAN_HUMAN; Otoancorin. 
    濃    度  1mg/1ml 
    規(guī) 格  0.2ml/200μg
    抗體來源  Rabbit  
    克隆類型  polyclonal 
    交叉反應  Human, Mouse, Rat
    產品類型  一抗    
    研究領域  神經(jīng)生物學 細胞粘附分子 細胞外基質  
    蛋白分子量  predicted molecular weight: 122kDa 
    性    狀  Lyophilized or Liquid 
    免 疫 原  KLH conjugated synthetic peptide derived from human OTOA/DFNB22 
    亞    型  IgG 
    純化方法  affinity purified by Protein A 
    ELISA試劑盒耳聾、常染色體隱性遺傳22抗體儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
    產品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
    (石蠟切片需做抗原修復) 
     not yet tested in other applications.
     optimal dilutions/concentrations should be determined by the end user.  
    保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
    Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
    ELISA試劑盒耳聾、常染色體隱性遺傳22抗體產品介紹 Otoancorin, also known as OTOA, CT108 or DFNB22, is a 1,153 amino acid protein belonging to the stereocilin family. Expressed in the inner ear and restricted to the interface between the apical surface of sensory epithelia, otoancorin is suggested to act as an adhesion molecule. Otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in the gene encoding otoancorin leads to deafness autosomal recessive type 22 (DFNB22), which is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain or the area of the brain that receives sound information. Existing as three alternatively spliced isoforms, otoancorin is encoded by a gene located on human chromosome 16p12.2.
    Function : May act as an adhesion molecule.
    Subcellular Location : Apical cell membrane. Secreted > extracellular space > extracellular matrix. At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.
    DISEASE : Defects in OTOA are the cause of deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Similarity : Belongs to the stereocilin family.
    Database links : UniProtKB/Swiss-Prot: Q7RTW8.1

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